: The Boss chooses to hunt down the Luchadores' leader. While successful, this leads to the destruction of a major city landmark and paints the Saints as public enemies, though they ultimately declare Steelport an independent city-state under their rule.

The war culminates in a massive showdown between the Saints, S.T.A.G., and the remaining Syndicate leaders. The story offers two distinct endings based on the player's final choice:

Stranded in , a city firmly under Syndicate control, the Boss and Shaundi must rebuild their criminal empire from scratch. Rebuilding the Empire