While hiding in a hospital, Sam is infected by a nurse’s blood. Surprisingly, the other "rabids" ignore him once they sense he is already "one of them".
Another possibility is , where the Season 11 premiere " Nangnangnangnang " introduced Jenny, the long-lost daughter of Charlie Harper, forcing the characters to face the "genetic legacy" and generational behavior patterns of their family. Content Breakdown: Supernatural S11E1 [S11E1] Premiere: Generations
Under the influence of Rowena’s attack dog spell, Castiel struggles with violent urges while seeking help from his angelic brothers. Content Breakdown: Two and a Half Men S11E1 While hiding in a hospital, Sam is infected
The show uses this generational shift to bridge the gap between its original premise and the post-Charlie Sheen era. Content Breakdown: Supernatural S11E1 Under the influence of
A mysterious fog turns people into mindless, black-veined killers known as "rabids".