If you are trying to mod a game, you would generally use a tool to extract the ISO contents, modify the files, and then rebuild the ISO.
Disclaimer: Handling unknown ISO files can pose a security risk. Only open files from trusted sources. Newstar Richie.iso
A personal, community-modded, or pirated ISO file. If you are trying to mod a game,
To play or test, you would use an emulator (e.g., PCSX2 for PS2, PPSSPP for PSP). 4. Where to Find Help modify the files
Right-click the file and select Mount . This will treat it as a virtual CD/DVD drive. macOS: Double-click the file to mount it.
The file might be mislabeled or misidentified. General Guide for Handling Unknown .iso Files