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: As of 2026, Ellen Pompeo , Chandra Wilson (Miranda Bailey), and James Pickens Jr. (Richard Webber) are the only original cast members still appearing on the show.

premiered on March 27, 2005, and has since become the longest-running primetime medical drama in TV history. Created by Shonda Rhimes , the series initially centered on Meredith Grey (portrayed by Ellen Pompeo ) and her fellow interns—Cristina, Izzie, George, and Alex—at Seattle Grace Hospital. Series Overview : As of 2026, Ellen Pompeo , Chandra

: The series remains a massive cultural staple and was recently renewed for a 23rd season . Iconic Quotes : As of 2026