G9048.mp4

Based on the full text of the study, supplemental videos (often named with similar codes) typically demonstrate:

: The resulting stiffened tissue triggers non-canonical activation of the transcription factor GLI2 in epithelial cells. g9048.mp4

: This signaling activates fibroblasts, which increase tissue stiffness by producing collagen. Based on the full text of the study,

: Injured epithelial cells release Sonic Hedgehog (SHH) ligands. g9048.mp4

: Visual evidence of cell mobility and invasiveness.