The DDR is a sophisticated signaling network that detects and repairs DNA lesions to maintain genomic stability.
: Activated by single-strand breaks and replication stress. Dnaddr Kim.zip
: Essential for non-homologous end joining (NHEJ) repair. Repair Pathways : The DDR is a sophisticated signaling network that
: DDR inhibitors are being heavily researched as targeted cancer therapies . By inhibiting these repair pathways, doctors can force malignant cells—which often already have mutations—into "cell death," especially when combined with radiation therapy. Potential Clarification Dnaddr Kim.zip
: A faster, more "error-prone" repair pathway used throughout the cell cycle.
: The system is primarily driven by three core kinases: ATM : Activated by double-strand breaks.
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