C4.zip

: The protein sample is aspirated through the tip, binding to the C4 resin.

: Best for proteins > 10 kDa and highly hydrophobic peptides. c4.zip

A C4 ZipTip is a standard pipette tip containing a microscopic bed of resin fixed at its distal end. Unlike C18 resins, which are used for smaller peptides, the C4 resin is optimized for larger, more hydrophobic molecules like proteins and large polypeptides. Primary Uses in Research Researchers use these tools for two main reasons: : The protein sample is aspirated through the

This technology has been instrumental in recent studies, including identifying SARS-CoV-2 protease cleavage sites and characterizing human cannabinoid receptors. which are used for smaller peptides

: Typically optimized for very small volumes (microliters).