Arsenical -

: There are documented instances of post-arsenical lichen planus , an inflammatory condition affecting the skin and mucous membranes. Timeline of Effects

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Post-arsenical obstructive jaundice complicated by xanthomatosis and diabetes mellitus. National Institutes of Health (.gov) Post-Arsenical Lichen Planus - PMC Post-Arsenical Lichen Planus - PMC. National Institutes of Health (.gov) Arsenic Poisoning: Causes, Symptoms & Treatment : There are documented instances of post-arsenical lichen

: A common subacute or chronic effect is peripheral neuropathy , which causes numbness, tingling ("pins and needles"), and weakness in the extremities. Internal Complications : AI responses may include mistakes

: Historic cases have documented post-arsenical obstructive jaundice , sometimes following treatments that used organic arsenicals (like those once used for syphilis).

: Chronic exposure often leads to distinctive skin changes that persist or appear after exposure stops. This includes hyperpigmentation (often described as a "raindrop" appearance) and hyperkeratosis , which are hard patches on the palms and soles.