Antitauon -

Using antisense oligonucleotides (ASOs) or "intrabodies" to reduce tau levels within the cell.

Using antibodies to bind to extracellular tau species, preventing them from being taken up by healthy neighboring neurons. antitauon

While many antitauon therapies have reached clinical trials, results have been mixed: similar to prions

Promoting the removal of pathological tau via microglia or through intracellular degradation pathways like the proteasome. Key Therapeutic Strategies antitauon

The concept of "tauons" arises from the observation that misfolded tau protein isoforms can propagate through the brain in a characteristic pattern, similar to prions, driving the progression of conditions like Alzheimer's disease. Antitauon therapies aim to intervene in this process through several key mechanisms: