The paper investigates how excess RA triggers its own degradation (via Cyp26 enzymes) and how depletion leads to compensatory receptor expression.
You can find the full text and original figures on the Wiley Online Library .
The research highlights that while direct activation of RA pathway genes via RAREs is understood, the mechanisms for negative feedback and suppression are still largely hypothetical. Accessing the Full Document 24227.rar
Input overload: Contributions of retinoic acid signaling feedback to retinoid homeostasis Authors: Andrea Janesick, Bruce Blumberg, and others.
The identifier appears to refer to a specific archived dataset or supplement associated with the scientific paper "Input overload: Contributions of retinoic acid signaling feedback to retinoid homeostasis" (published in Developmental Dynamics ). Full Paper Details The paper investigates how excess RA triggers its
The paper explores how retinoic acid (RA) signaling uses feedback loops to maintain stable levels of Vitamin A metabolites, specifically examining the role of Retinoic Acid Receptors (RARs) and enzymes like Cyp26. Content Summary
Developmental Dynamics , Volume 244, Issue 3 (November 24, 2014). Accessing the Full Document Input overload: Contributions of
A version of the manuscript is also available through PMC (National Library of Medicine) .