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: Show that mice unable to form the PKG disulfide bond (C42S KI) exhibit different blood pressure responses compared to wild-type (WT) mice.

: Protein Kinase G Iα (PKG Iα) is usually activated by cGMP, but it can also be activated by "oxidative stress" (specifically the formation of a disulfide bond at Cys42). 23484.rar

: Targeting the Oxidative Activation of Protein Kinase G Iα: A Novel Therapeutic Approach for Hypertension. : Show that mice unable to form the